Tracking Compounds and Their Interactions within In Silico Liver
نویسندگان
چکیده
We present multi-scale tracking features for the In Silico Liver (ISL) and their simulation results. The features were developed to support tracking of dynamic pharmacokinetic/pharmacodynamic (PK/PD) hepatic disposition phenomena that occur within an ISL during and after injection. Trackable components include molecules, enzymes, binders, cells, and features of tissue microarchitecture. Tracking has been performed across several levels of biological resolution including lobule, sinusoidal network, sinusoidal segments, cells, and binders. By tracking compounds and their spatiotemporal interactions, we could observe and analyze the reactive PK/PD responses and proactive hepatic events at the system level. Exploratory simulation experiments using ISLs in their normal and pathological states are expected to enable unraveling of the sophisticated biological realities that occur inside the liver at various scales.
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